02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma

Grant Status: Open

Grant Amount: $334,306
Erin B. Dickerson, PhD and Antonella Borgatti, DVM, MS; University of Minnesota
July 1, 2019 - June 30, 2024

Sponsor(s): American Belgian Tervuren Club, Inc., American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health and Genetics Institute, Inc., Bearded Collie Club of America, Bearded Collie Club of America Charitable Trust, Briard Club of America Health & Education Trust, Clumber Spaniel Health Foundation, Golden Retriever Foundation, Gordon Setter Club of America, Inc., Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Irish Setter Club of America Foundation, Irish Setter Club of Milwaukee, Inc., Labrador Retriever Club, Inc., Nespola Charitable Foundation, Old English Sheepdog Club of America, Portuguese Water Dog Foundation, Inc., Rhodesian Ridgeback Charitable Foundation, Rottweiler Health Foundation, Samoyed Club of America Education & Research Foundation, SCWTCA Endowment, Inc., The Kennel Club of Philadelphia, Vizsla Club of America Welfare Foundation

Breed(s): -All Dogs
Research Program Area: Oncology - Hemangiosarcoma
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One Health: Yes


Co-investigators: David R. Brown, PhD; University of Minnesota, Michael O. Childress, DVM, MS; Purdue University, Jennifer Mahoney, DVM and Pascale Salah; University of Pennsylvania

Canine hemangiosarcoma is a largely incurable cancer in dogs, and treatment approaches to improve outcomes have remained relatively stagnant over the past few decades. Treatment remains a challenge partly because the cancer is frequently detected at an advanced stage and because these tumors are often resistant to chemotherapies. Recently published reports showed that propranolol, a drug used to treat heart disease in humans and dogs, substantially increased the survival time of human angiosarcoma patients when used in combination with standard of care treatments. Propranolol was also shown to sensitize hemangiosarcoma cells to doxorubicin, providing a more effective way to kill tumor cells. Because angiosarcoma is strikingly similar to canine hemangiosarcoma, this multi-institutional clinical trial has been designed to determine the efficacy of propranolol in dogs with hemangiosarcoma when used in combination with surgery and chemotherapy. The main goal of the study is to establish whether propranolol in combination with doxorubicin following surgery improves outcomes for dogs when compared to the use of chemotherapy and surgery alone. The investigators will also evaluate the plasma concentrations of propranolol achieved during dosing to assess whether the levels of propranolol correlate to survival times. If successful, the findings from this approach will be rapidly conveyed to the veterinary community, and the guidelines provided to clinicians for the use of propranolol and doxorubicin for the treatment of canine hemangiosarcoma.

Learn how you can participate in this study!


“Repurposing Old Drugs for New Cancer Treatments.” Accessed May 5, 2023. https://www.dvm360.com/view/repurposing-old-drugs-for-new-cancer-treatments.

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